abstract：:Strychnine is known to possess anti-inflammatory and antitumour activity, but its roles in tumour angiogenesis, the key step involved in tumour growth and metastasis, and the involved molecular mechanism are still unknown. We aimed to investigate the effects of strychnine on key components of inflammatory angiogenesis...

journal_title：Microvascular research

authors： Saraswati S,Agarwal SS

更新日期：2013-05-01 00:00:00

abstract：:Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse a...

journal_title：Microvascular research

authors： Sharma B,Albig AR

更新日期：2013-01-01 00:00:00

abstract：:The steroid hormone estradiol is suggested to play a protective role in intestinal injury during systemic inflammation (sepsis). Our aim was to determine the effects of specific estradiol receptor (ER-α and ER-ß) agonists on the intestinal microcirculation during experimental sepsis. Male and sham ovariectomized femal...

journal_title：Microvascular research

authors： Sharawy N,Ribback S,Al-Banna N,Lehmann C,Kern H,Wendt M,Cerny V,Dombrowski F,Pavlovic D

更新日期：2013-01-01 00:00:00

abstract：:Hemorrhage is responsible for a large percentage of trauma-related deaths but the mechanisms underlying tissue ischemia are complex and not well understood. Despite the evidence linking glycocalyx degradation and hemorrhagic shock, there is no direct data obtained in vivo showing glycocalyx thickness reduction in skel...

journal_title：Microvascular research

authors： Torres Filho I,Torres LN,Sondeen JL,Polykratis IA,Dubick MA

更新日期：2013-01-01 00:00:00

abstract：:Vascular dysfunction is an important pathophysiologic manifestation of sickle cell disease (SCD), a condition that increases risk of pulmonary hypertension and stroke. We hypothesized that infrared (IR) imaging would detect changes in cutaneous bloodflow reflective of vascular function. We performed IR imaging and con...

journal_title：Microvascular research

authors： Gorbach AM,Ackerman HC,Liu WM,Meyer JM,Littel PL,Seamon C,Footman E,Chi A,Zorca S,Krajewski ML,Cuttica MJ,Machado RF,Cannon RO 3rd,Kato GJ

更新日期：2012-11-01 00:00:00

abstract：:Vessel size index (R(v), μm) has been proposed as a quantitative magnetic resonance imaging (MRI) derived imaging biomarker in oncology, for the non-invasive assessment of tumour blood vessel architecture and vascular targeted therapies. Appropriate pre-clinical evaluation of R(v) in animal tumour models will improve ...

journal_title：Microvascular research

authors： Burrell JS,Bradley RS,Walker-Samuel S,Jamin Y,Baker LC,Boult JK,Withers PJ,Halliday J,Waterton JC,Robinson SP

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Angiogenin levels are increased in children and adolescent patients with type 1 diabetes, regardless of the extent of diabetic microangiopathy. However, little is known about the angiogenin concentrations in adults with type 1 diabetes. Thus we studied its level in middle aged subjects with the presence of d...

journal_title：Microvascular research

authors： Neubauer-Geryk J,Kozera GM,Wolnik B,Szczyrba S,Nyka WM,Bieniaszewski L

更新日期：2012-11-01 00:00:00

abstract：:Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicate...

journal_title：Microvascular research

authors： Woolnough C,Wang Y,Kan CY,Morris JM,Tasevski V,Ashton AW

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis activity are implicated in diabetic vascular complications. We measured serum AGE, sRAGE and pentosidine levels in Tunisian patients with diabetic retinopathy (DR) and examined whether these biomarkers are related to the severity of DR. ...

journal_title：Microvascular research

authors： Kerkeni M,Saïdi A,Bouzidi H,Ben Yahya S,Hammami M

更新日期：2012-11-01 00:00:00

abstract：:Growing interest in utilizing endothelial cells (ECs) for therapeutic purposes has led to the exploration of human embryonic stem cells (hESCs) as a potential source for endothelial progenitors. In this study, ECs were induced from hESC lines and their biological characteristics were analyzed and compared with both co...

journal_title：Microvascular research

authors： Sun X,Cheng L,Duan H,Lin G,Lu G

更新日期：2012-09-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) and their receptors play important roles in cellular processes such as proliferation, differentiation, migration and cell survival. It was also demonstrated that BMPs are involved in vasculogenesis and angiogenesis. In this study, we investigated the expression profile of BMP recepto...

journal_title：Microvascular research

authors： Finkenzeller G,Hager S,Stark GB

更新日期：2012-07-01 00:00:00

abstract：:Endotoxemia, a major feature of sepsis, is a common cause of acute lung injury and initiates rapid accumulation of leukocytes in the lung vasculature. Endothelial mechanisms that underlie this accumulation remain unclear, as current experimental models of endotoxemia are less suitable for targeted activation of the en...

journal_title：Microvascular research

authors： Kandasamy K,Sahu G,Parthasarathi K

更新日期：2012-05-01 00:00:00

abstract：:The relative magnitude of vascular reactivity to inhaled gas stimuli in the major retinal arterioles has not been systematically investigated. The purpose of this study was to compare the magnitude of retinal vascular reactivity in response to inhaled gas provocation at equivalent measurement sites in the superior-, a...

journal_title：Microvascular research

authors： Sehi M,Tsui E,Cheng R,Wan J,Wong T,Dorner S,Fisher J,Hudson C

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Tissue ischemia and reperfusion (I/R) affects blood flow restoration and oxygen delivery to the damaged tissues contributing to tissue morbidity and microcirculatory compromise. Pulsed acoustic cellular expression (PACE) technology is known to support tissue neovascularization. The aim of this study was to t...

journal_title：Microvascular research

authors： Krokowicz L,Klimczak A,Cwykiel J,Mielniczuk M,Grykien C,Siemionow M

更新日期：2012-03-01 00:00:00

abstract：:Overexpression of EGFR plays a key-role in head and neck squamous cell carcinoma (HNSCC) and justifies the extensive use of cetuximab, a monoclonal anti-EGFR antibody, as well as EGFR-tyrosine kinase inhibitors (EGFR-TKI), which have been reported to inhibit tumor cell growth and the secretion of pro-angiogenic factor...

journal_title：Microvascular research

authors： Jouan-Hureaux V,Boura C,Merlin JL,Faivre B

更新日期：2012-03-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a key component of cell-substratum adhesions, known as focal adhesion complexes. Growing evidence indicates that FAK is important in maintenance of normal cell survival and that disruption of FAK signaling results in loss of substrate adhesion and anoikis (apoptosis) of anchorage-depende...

journal_title：Microvascular research

authors： Lu Q,Rounds S

更新日期：2012-01-01 00:00:00

abstract：:Injection of labeled microspheres is an established method in animal models to analyze the capillary organ blood flow at different time points. However, the microspheres can lead to stenoses of the capillary lumen, which might affect tissue oxygen supply. Our study aimed to investigate the influence of repeated inject...

journal_title：Microvascular research

authors： Hiebl B,Mrowietz C,Lee S,Braune S,Knaut M,Lendlein A,Franke RP,Jung F

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Calcium channel inhibitors have beneficial impact on microcirculation, but beta-blocker effect is controversial. Clinicians still do not agree on beta-blocker combination with other treatments in the management of impaired microcirculation. The aim of the present study was to describe the effects of beta-blo...

journal_title：Microvascular research

authors： Csiki Z,Garai I,Shemirani AH,Papp G,Zsori KS,Andras C,Zeher M

更新日期：2011-07-01 00:00:00

abstract：:A well developed capillary bed is essential for proper function of skeletal muscles. We present for the first time a triple immunofluorescent method suitable for staining capillaries and muscle fibre outlines in thick sections of human skeletal muscle, applying antibodies against collagen IV (in red) and F8 (in green)...

journal_title：Microvascular research

authors： Janáček J,Cvetko E,Kubínová L,Travnik L,Eržen I

更新日期：2011-03-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) orchestrates angiogenesis under hypoxic conditions mainly due to increased expression of such target genes as vascular endothelial growth factor (VEGF). Na+/H+exchanger-1 (NHE1), a potential HIF target gene product, plays a pivotal role in proliferation, survival, migration, adhesion...

journal_title：Microvascular research

authors： Mo XG,Chen QW,Li XS,Zheng MM,Ke DZ,Deng W,Li GQ,Jiang J,Wu ZQ,Wang L,Wang P,Yang Y,Cao GY

更新日期：2011-03-01 00:00:00

abstract：:There is evidence that vascular beds distal to the ophthalmic artery (OA) show vasoconstriction in response to a step decrease in systemic blood pressure (BP). The mediators of this response are mostly unidentified. The aim of the current study was to test the hypothesis that α2-adrenoreceptors may contribute to the r...

journal_title：Microvascular research

authors： Kaya S,Kolodjaschna J,Berisha F,Polska E,Pemp B,Garhöfer G,Schmetterer L

更新日期：2011-01-01 00:00:00

abstract：:Endothelial cells and endothelial progenitor cells (EPCs) play a key role in the pathogenesis of vascular disease. Both cell types are affected by the oxidative stress but their susceptibility may be different. This study aimed to investigate the antioxidative enzymes activated in EPCs after high constant glucose expo...

journal_title：Microvascular research

authors： Felice F,Lucchesi D,di Stefano R,Barsotti MC,Storti E,Penno G,Balbarini A,Del Prato S,Pucci L

更新日期：2010-12-01 00:00:00

abstract：:Normal brain parenchyma has a highly complex microvascular structure that undergoes re-modelling in the presence of a tumor. A detailed understanding of the clinical and pathological aspects of neo-angiogenesis in malignant human brain tumors is essential in order to ensure the successful clinical application of anti-...

journal_title：Microvascular research

authors： Di Ieva A

更新日期：2010-12-01 00:00:00

abstract：:Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated in various models of pulmonary arterial hypertension (PAH). We addressed the relationship between P...

journal_title：Microvascular research

authors： Maniatis NA,Balyasnikova IV,Metzger R,Castellon M,Visintine DJ,Schwartz DE,Minshall RD,Danilov SM

更新日期：2010-09-01 00:00:00

abstract：:P120 catenin (p120ctn) belongs to the family of Armadillo repeat-containing proteins, which are believed to have dual functions of cell-cell adhesion and transcriptional regulation. In vascular endothelium, p120ctn is mostly recognized for its cell-cell adhesion function through its ability to regulate VE-cadherin. Th...

journal_title：Microvascular research

authors： Zhang J,O'Donnell JJ 3rd,Holian O,Vincent PA,Kim KS,Lum H

更新日期：2010-09-01 00:00:00

abstract：:Changes in blood vessel diameter can be measured manually, but this is time-consuming and often impractical. For automatic measurement commercial solutions are available, but the proprietary algorithms and their potential shortcomings are not known to the user. We present an approach with a CCD camera for image acquis...

journal_title：Microvascular research

authors： Fischer MJ,Uchida S,Messlinger K

更新日期：2010-09-01 00:00:00

abstract：:This paper presents the results of a circulation analysis using an image based network model of a murine retinal vasculature, which closely represents the 3D vascular distribution of the retina. The uneven distribution of the red blood cells at vascular network bifurcations (i.e., plasma skimming effect), the microvas...

journal_title：Microvascular research

authors： Ganesan P,He S,Xu H

更新日期：2010-07-01 00:00:00

abstract：:Developing tissue engineering approaches to generate functional vascular networks is important for improving treatments of peripheral and cardiovascular disease. Endothelial colony forming cells (ECFCs) are an endothelial progenitor cell (EPC) population defined by high proliferative potential and an ability to vascul...

journal_title：Microvascular research

authors： Critser PJ,Kreger ST,Voytik-Harbin SL,Yoder MC

更新日期：2010-07-01 00:00:00

abstract：:The first description of endothelial progenitor cells (EPC) in 1997 led rapidly to substantial changes in our understanding of angiogenesis, and within 5 years to the first clinical studies in humans using bone marrow derived EPC to enhance coronary neovascularisation and cardiac function after myocardial ischemia. Ho...

journal_title：Microvascular research

authors： Pearson JD

更新日期：2010-05-01 00:00:00

abstract：:We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin...

journal_title：Microvascular research

authors： Derosa G,D'Angelo A,Salvadeo SA,Ferrari I,Fogari E,Gravina A,Mereu R,Palumbo I,Maffioli P,Randazzo S,Cicero AF

更新日期：2010-03-01 00:00:00

abstract：:The present study was conducted to compare laser speckle imaging (LSI) with sidestream dark field (SDF) imaging (i.e., capillary microscopy) so as to validate the use of LSI for assessing microvascular (re)perfusion. For this purpose, LSI and SDF measurements were performed on the human nail fold during gradual occlus...

journal_title：Microvascular research

authors： Bezemer R,Klijn E,Khalilzada M,Lima A,Heger M,van Bommel J,Ince C

更新日期：2010-03-01 00:00:00

abstract：:Living mesenteric capillaries with either an intact or disrupted glycocalyx were challenged with ramp change in shear stress (Deltatau). Animals (Rana pipiens) were divided randomly into two experimental groups, and two true capillaries (TC) per animal were investigated. The modified Landis technique was combined with...

journal_title：Microvascular research

authors： Williams DA

更新日期：2010-03-01 00:00:00

abstract：:We explored the role of 20-hydroxy-5Z, 8Z, 11Z, 14Z-eicosatetraenoic acid (20-HETE) in oxygen-induced vasoconstriction in a normal renin form of hypertension [the 1 kidney-1 clip Goldblatt hypertensive rat (1K1C)] and a high renin form of hypertension [the 2 kidney-1 clip Goldblatt hypertensive rat (2K1C)]. A silver c...

journal_title：Microvascular research

authors： Kunert MP,Friesma J,Falck JR,Lombard JH

更新日期：2009-12-01 00:00:00

abstract：:Most forms of tissue healing depend critically on revascularisation. In soft tissues and in vitro, mechanical stimuli have been shown to promote vessel-forming activity. However, in bone defects, increased interfragmentary motion impairs vascular regeneration. Because these effects seem contradictory, we aimed to dete...

journal_title：Microvascular research

authors： Wilson CJ,Kasper G,Schütz MA,Duda GN

更新日期：2009-12-01 00:00:00

abstract：:Thermal injuries of more than 20% body surface area (BSA) result in systemic capillary leakage with subsequent edema. This can similarly be induced by burn plasma transfer (BPT) from burned individuals to healthy rats. We evaluated if cerium nitrate (CN) bathing can prevent edema after BPT. Therefore, donor rats (DR) ...

journal_title：Microvascular research

authors： Kremer T,Hernekamp F,Riedel K,Peter Ch,Gebhardt MM,Germann G,Heitmann Ch,Walther A

更新日期：2009-12-01 00:00:00

abstract：:Post occlusive skin reactive hyperemia (PORH) is a tool used to assess microcirculation. Endothelial nitric oxide synthase (eNOS) mediates nitric oxide (NO) production; polymorphism of the eNOS gene may affect response to the PORH process. This study aims to determine whether eNOS G894T gene polymorphism affects respo...

journal_title：Microvascular research

authors： Rasool AH,Ghazali DM,Abdullah H,Halim AS,Wong AR

更新日期：2009-09-01 00:00:00

abstract：:Endothelial dysfunction is common in patients with chronic kidney disease (CKD) and contributes significantly to the high long-term cardiovascular morbidity and mortality. The short-term cardiovascular effects of recombinant human growth hormone (rhGH) in CKD patients (stages III-V) and healthy controls (n=15 each) we...

journal_title：Microvascular research

authors： Nissel R,Fischer DC,Puhlmann A,Holdt-Lehmann B,Mitzner A,Petzsch M,Körber T,Tiess M,Schmidt R,Haffner D

更新日期：2009-09-01 00:00:00

abstract：:A large loss of blood during hemorrhage can result in profound shock, a state of hypotension associated with hemodynamic abnormalities. One of the hypotheses to account for this collapse of homeostasis is that the production of nitric oxide (NO), a gas molecule that dilates blood vessels, is significantly impaired dur...

journal_title：Microvascular research

authors： Chen K,Pittman RN,Popel AS

更新日期：2009-06-01 00:00:00

abstract：:It has generally been assumed that movement of fluid between the pulmonary microvasculature and surrounding tissues is governed by a "Starling" balance of hydrostatic and protein osmotic forces similar to that which prevails in the extremities. However, both recent and older observations suggest that the lungs are mor...

journal_title：Microvascular research

authors： Effros RM,Parker JC

更新日期：2009-06-01 00:00:00

abstract：:Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. Emerging data suggest that platelets may play an important role in tissue damage and inflammation. Herein, we characterized the platelet response in cholestatic liver injury and evaluated the role of Rho-kinase signaling. For...

journal_title：Microvascular research

authors： Laschke MW,Dold S,Menger MD,Jeppsson B,Thorlacius H

更新日期：2009-06-01 00:00:00